The striker has not started for Spurs for five weeks due to an ankle ligament problem and his return to fitness represent a huge boost for Mauricio Pochettino's side.
Victor Wanyama has recovered from a back problem to take his place on the bench, which means Eric Dier has retained a starting berth in central midfield.
The north Londoners have been in superb form on home turf this season and will be keen to extend their unbeaten record at the expense of the Cherries.
Eddie Howe's side are not yet mathematically safe and recent positive results at Old Trafford and Anfield suggest they will not be content to sit back at White Hart Lane.
Tottenham XI: Lloris, Walker, Alderweireld, Vertonghen, Davies, Dier, Dembele, Son, Eriksen, Alli, Kane.
Tottenham subs: Lopez, Trippier, Wimmer, Wanyama, Onomah, Sissoko, Janssen.
Bournemouth XI: Boruc, Smith, Francis, Cook, Daniels, Stanislas, Arter, Wilshere, Pugh, King, Afobe.
Bournemouth subs: Allsop, Mings, Cargill, Cook, Fraser, Gradel, Mousset.
What they're saying
Mauricio Pochettino: “We have to take the next game like it’s a final, forget the past and focus on the present.
"We must show concentration, focus and try to play well. That is our challenge, to forget what happened before because we can’t win with history.
"We can only win if we deserve to win."
Eddie Howe: "I was very impressed with (Spurs) last season and if anything I’m even more impressed with them this season.
"Last year, probably with Manchester City, they were our toughest opponents and the game will be one of our toughest this year.
“They have a young squad and a great manager so the future looks bright.”