Vincent Janssen started the weekend's win over Burnley but has had to settle for a place on the substitutes' bench.
Victor Wanyama has not recovered from a back problem while Michel Vorm has been handed a rare start ahead of Hugo Lloris, who has not been included in the matchday squad at all after falling ill this afternoon.
Mauricio Pochettino appears to have reverted to a 4-2-3-1 formation as the north Londoners attempt to keep up the pressure on pacesetters Chelsea.
Mousa Dembele and Eric Dier are set to play in central midfield while Moussa Sissoko has been given a chance to impress.
Spurs have lost just one of their 14 last top-flight fixtures and will be keen to extend that record at the expense of the Swans, who are languishing just one point clear of the relegation zone.
Tottenham XI: Vorm, Walker, Alderweireld, Vertonghen (C), Davies, Dier, Dembele, Sissoko, Eriksen, Dele, Son.
Tottenham subs: Lopez, Carter-Vickers, Wimmer, Trippier, Onomah, Nkoudou, Janssen.
Swansea XI: Fabianski; Naughton, Fernandez, Mawson, Olsson; Carroll, Fer, Cork; Routledge, Ayew, Sigurdsson.
Swansea subs: Fabianski; Naughton, Fernandez, Mawson, Olsson; Carroll, Fer, Cork; Routledge, Ayew, Sigurdsson.
What they're saying
Mauricio Pochettino: “We expect a tough game - they are fighting to survive.
"Every game we play against the teams playing for survival or playing for the title, they are all very tough.
"We need to continue to be consistent, to focus, to be concentrated and be ready to play."
Paul Clement: “I think it will be an interesting game for us. They will want to win here and we need points too.
"The Chelsea result at the weekend has probably given them belief that they can take the title race right to the end of the season."