Mauricio Pochettino is still without injured striker Harry Kane and has opted for the Dutchman to lead his side's frontline at Turf Moor.
Harry Winks has been handed an opportunity to impress in central midfield while Kieran Trippier starts ahead of Kyle Walker at right wing-back.
Spurs will solidify their place in the top-four with victory over Sean Dyche's men but just three sides have taken all three points off of the Clarets in front of their home fans.
The hosts secured a valuable draw against pacesetters Chelsea on their last appearance on home turf and will relish another opportunity to test themselves against one of the division's best teams.
Tottenham XI: Lloris, Trippier, Dier, Alderweireld, Vertonghen, Davies, Wanyama, Winks, Eriksen, Dele, Janssen.
Tottenham subs: Vorm, Carter-Vickers, Walker, Dembele, Sissoko, Nkoudou, Son.
Burnley XI: Heaton; Lowton, Keane, Mee, Ward; Boyd, Barton, Hendrick, Arfield; Gary, Barnes.
Burnley subs: Flanagan, Brady, Westwood, Vokes, Tarkowski, Defour, Robinson.
What they're saying
Mauricio Pochettino: “It will be a very tough game, Burnley are doing very well at home.
"They’ve had some unbelievable results there and for us, it’s a big, big challenge.
"They believe in the way they play and they fight, it’s a strong team, very physical."
Sean Dyche: "They [Spurs] are one of the top sides in the division and I really like the way they go about their business.
“They can mix the game up and play with pace and pass through the units very quickly.”