Spurs' temporary move to Wembley is expected to be confirmed in the days leading up the kick-off in what is the biggest meeting between the two sides in recent memory, perhaps longer.
Spurs look to finish above their fierce rivals for the first time since Arsene Wenger's appointment 21 years ago, boasting a team arguably superior in most positions for the first time in decades.
A FA Cup semi-final win over Manchester City has made slight amends for Arsenal's dire league form this season, they go into the game in fifth place and 14 points behind Spurs. It's more than pride at stake on Sunday.
Scroll down for Standard Sport's comprehensive preview...
Tottenham host Arsenal at White Hart Lane with kick-off scheduled for April 30 at 4.30pm.
TV AND LIVE ONLINE COVERAGE
The match will be televised live on Sky Sports 1, with coverage starting from 4.15pm. Alternatively, you can follow all the build-up and action from 3.30pm with Standard Sport’s London Football live blog.
Can't see the live blog? Click here for the desktop version.
Tottenham earned a hard-fought win over Crystal Palace with no fresh injury concerns, while Danny Rose has returned to training this week.
Ben Davies has deputised, to praise, in Rose's three-month absence but Mauricio Pochettino hinted at a return for the England international on Sunday.
Laurent Koscielny is a doubt after suffering a knee injury during Arsenal's own tense Wednesday night victory, over Leicester City.
Speaking after the game, Arsene Wenger said the centre-back will be assessed ahead of the short Sunday trip to N17.
Tottenham starting XI: Lloris; Alderweireld, Dier, Vertonghen; Walker, Wanyama, Dembele, Davies; Alli, Eriksen; Kane
Arsenal starting XI: Cech; Gabriel, Koscielny, Holding; Oxlade-Chamberlain, Xhaka, Ramsey, Monreal; Ozil, Sanchez; Giroud
BETTING ODDS (via 888 Sport)
- Tottenham to win: 19/20
- Arsenal to win: 14/5
- Draw: 11/4
Click here to place a bet. Odds correct as of April 26 at 5pm.