Spurs play a day before Premier League champions elect Chelsea face Manchester United at Old Trafford and can heap the pressure on their title rivals with a win over the Cherries.
Eddie Howe's men have pulled clear of relegation trouble in recent weeks, but couldn't do Spurs a favour as they suffered a setback against Antonio Conte's men last weekend.
Bournemouth haven't beaten Tottenham since promotion to the Premier League in 2015 and Saturday will likely be their last chance to get a first victory at White Hart Lane.
Scroll down for Standard Sport's comprehensive preview...
Tottenham host Bournemouth at White Hart Lane, with kick-off scheduled for 12.30pm on Saturday, April 15.
TV AND LIVE ONLINE COVERAGE
The match will be televised live in the UK on Sky Sports 1, with coverage starting at 11.30am. You can follow all the build-up and action from 11am with Standard Sport’s London Football live blog. Enter your email address below to be informed when coverage begins.
Harry Kane is set to make his first start in almost five weeks, having come off the bench against Watford last time out.
Victor Wanyama is expected to return after missing two matches with a back complaint. Michel Vorm is struggling with a knee problem.
Danny Rose (knee), Erik Lamela (hip) and Harry Winks (ankle) are all out.
Provisional squad: Lloris, Vorm, Lopez, Davies, Alderweireld, Vertonghen, Dier, Carter-Vickers, Wimmer, Walker, Trippier, Wanyama, Dembele, Eriksen, Alli, Sissoko, Onomah, Son, Janssen, Kane.
Dan Gosling remains doubtful for Bournemouth after suffering a setback to his recovery from a knee problem.
Defender Tyrone Mings is available again after serving out his five-match suspension for a stamp on Manchester United forward Zlatan Ibrahimovic, while winger Junior Stanislas could feature having been sidelined by a groin strain.
Midfielder Andrew Surman, though, may well be sidelined for the remainder of the campaign with a knee problem, while forward Callum Wilson, goalkeeper Adam Federici and defender Rhoys Wiggins all continue their recoveries from their own knee injuries.
Provisional Squad: Boruc, A Smith, S Cook, Daniels, Francis, Pugh, Wilshere, Arter, Fraser, Afobe, King, Allsop, Ibe, Mousset, Gradel, B Smith, L Cook, Cargill, Mings, Stanislas, Gosling.
Tottenham starting XI: Lloris, Walker, Alderweireld, Vertonghen, Davies, Wanyama, Dembele, Eriksen, Alli, Son, Kane
Bournemouth starting XI: Boruc, Smith, Francis, Cook, Daniels, Arter, Wilshere, Fraser, King, Pugh, Afobe
BETTING ODDS (via 888 Sport)
- Tottenham to win: 11/50
- Bournemouth to win: 13/1
- Draw: 23/4
Click here to place a bet. Odds correct as of April 15 at 9am.