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Manager Antonio Conte revealed on Monday that the club were waiting for the results of follow-up PCR tests on two players, with the club hoping to avoid another outbreak in the squad.
The two individuals concerned, believed to include one of Conte's key players, missed training on Tuesday but the head coach remained hopeful they could be involved tonight.
The Italian reverted to his preferred side for the last-gasp 1-0 win over Watford on New Year’s Day and he may be inclined to stick with the same team here – before making wholesale changes for Sunday’s FA Cup third-round tie at home to Morecambe.
Spurs remain without injured trio Ryan Sessegnon, Steven Bergwijn and Cristian Romero, although Sessegnon is expected to be back in contention to face Morecambe.
Giovani Lo Celso will be hoping for more minutes after returning from injury at Vicarage Road but only starts on the bench here.
Tottenham starting XI (3-4-2-1): Lloris; Sanchez, Tanganga, Davies; Doherty, Skipp, Hojbjerg, Royal ; Lucas, Son; Kane.
When: Wednesday, January 5, 2022. Kick-off at 7.45pm GMT.
Where: Stamford Bridge, London
TV channel: Sky Sports
Spurs squad from: Lloris, Gollini, Austin, Royal, Doherty, Tanganga, Davies, Reguilon, Dier, Rodon, Sanchez, Winks, Hojbjerg, Skipp, Ndombele, Dele, Lo Celso, Son, Gil, Lucas, Kane.
Out: Sessegnon (muscular), Bergwijn (calf), Romero (hamstring).