Undefeated welterweight champion Usman collides with arch-nemesis Covington after months of bad blood between the two while Max Holloway puts his featherweight strap on the line against Alexander Volkanovski.
Pound-for-pound great and two-weight world champion Amanda Nunes also puts her bantamweight title on line against Germaine de Randamie, searching for her 10th straight win.
Jose Aldo also features on a stacked card, moving down to bantamweight to take on Marlon Moraes, hoping victory will propel him towards a title shot against the 135lbs champion Henry Cejudo.
Date, UK start time and venue
UFC is back in Las Vegas on Saturday 14 December.
That location means it is an early start Sunday morning for UK viewers with the main card getting underway at 3am GMT.
Prelim coverage begins at 1am.
TV channel and live stream
The match will be televised live on BT Sport 1, with coverage starting from 1am.
Card in full
- Kamaru “The Nigerian Nightmare” Usman vs. Colby “Chaos” Covington
- Max “Blessed” Holloway vs. Alexander “The Great” Volkanovski
- Amanda “The Lioness” Nunes vs. Germaine “The Iron Lady” de Randamie
- Marlon “Magic” Moraes vs. Jose Aldo
- Petr “No Mercy” Yan vs. Urijah “The California Kid” Faber
- Geoff “Handz of Steel” Neal vs. Mike “Platinum” Perry
- Ketlen “Fenomeno” Vieira vs. Irene Aldana
- Ian “The Hurricane” Heinisch vs. Omari “Wolverine” Akhmedov
- Matt “The Immortal” Brown vs. Ben “Killa B” Saunders
- Chase “The Dream” Hooper vs. Daniel “Kid Dynamite” Teymur
- Brandon “The Assassin Baby” Moreno vs. Kai “Don’t Blink” Kara France
- Jessica “Evil” Eye vs. Viviane “Vivi” Araujo
- Punahele “Puna” Soriano vs. Oskar “Imaldo” Piechota