The latest figures represent a decrease of 39 per cent, or 12,813 cases, from the number of daily infections recorded just over a week ago on Thursday, April 14.
Meanwhile, the UK has recorded 185,625 cases in the latest seven-day period from April 16 to 22.
This is a six per cent drop – or 11,929 fewer cases – than the week prior.
However, the death toll in the past seven days has risen by almost 20 per cent with 1,956 deaths recorded.
Latest data shows 16,832 cases in London in the past seven days.
Covid-19 infections have plummeted simultaneously in all four UK nations for the first time since the middle of January.
Wales has seen infections drop for the first time in seven weeks, while in Northern Ireland cases have dropped to levels last seen before Christmas 2021.
England and Scotland have also recorded falls, suggesting the recent surge in infections driven by the Omicron BA.2 variant has peaked.
Across the UK, 3.8 million people in private households are estimated to have had Covid-19 in the week to April 16, down from 4.4 million the previous week.
Total infections in the UK hit a weekly record of 4.9 million in late March.
In England, infections have dropped for the second week running, with 3.2 million people likely to test positive for Covid-19, or one in 17 – down from 3.8 million, or one in 14.
Professor James Naismith of the University of Oxford said the figures showed that prevalence of the virus “peaked around the middle of March” and that “all things being equal, a fall in prevalence should feed through to reduced pressure in hospitals which are clearly under extreme stress.”
He added: “This will lead to a fall in deaths, which have continued to rob families of their loved ones.”
The figures come as the number of people in hospital with Covid-19 in the UK shows early signs of being on a downwards trend, having peaked at around the same level that was reached during the first Omicron surge in January.
Deaths involving Covid-19 are continuing to rise slowly, but remain well below the numbers seen during the first and second waves of the virus.