Vladimir Nesterov, who developed the Angara rocket and was head of the Khrunichev Centre, passed away at the age of 74.
The cause of his death has not been revealed by officials.
In 2014, Mr Nesterov was accused of allegations of fraud and embezzlement. Authorities had previously accused him of taking £57million and he had arrested pending a further investigation.
Mr Nesterov is the latest high-profile Russian to die in somewhat mysterious circumstances.
The 66-year-old had been on a trip to celebrate his 66th birthday in Rayagada, India and, according to local reports, he jumped from a hotel roof.
In July, he posted a story on his WhatsApp messaging app, criticising Russia’s missile attacks on Kyiv as “terrorism” but he later deleted the post.
General Alexei Maslov, 69, former commander of Russian ground forces with close ties to Ukraine, died “suddenly” the day after Vladimir Putin cancelled a trip to the tank enterprise where he worked as an international sales ambassador.
Alexander Buzakov, 65, director general of Admiralty Shipyards, in charge of building new submarines armed with deadly Kalibr missiles also died suddenly on Christmas Day.