Losses to Scotland and England have left the Welsh fourth in the table and facing a potential Group of Death at the 2019 Rugby World Cup in Japan.
Wales must win one of their remaining two Six Nations matches or they will almost certainly drop out of the top eight of the World Rugby rankings.
Should they do so, they would slip into pot three for the World Cup first round draw on May 10.
Here’s the full breakdown ahead of Friday's clash at the Principality Stadium…
The match kicks off at Twickenham at 8.05pm on Friday, March 10.
TV AND LIVE COVERAGE
BBC will be broadcasting the match live with build-up from 7.30pm, while BBC Five Live Sports Extra will provide coverage on the radio.
You can follow the match live online by clicking here.
Number eight Taulupe Faletau and lock Luke Charteris both appear on course to start for the first time in this season's tournament, but that could be the total extent of any Wales switches.
Meanwhile, Jared Payne is unlikely to feature in Ireland's crucial RBS 6 Nations clash in Wales on Friday after missing training on Monday.
Ulster centre Payne has made an unlikely return to the Ireland squad for the Six Nations' final two rounds, after fighting back from long-term kidney damage suffered against Australia in November.
Full-back Rob Kearney completed Monday's session with no ill effects, so should now be ready to start in Wales after shaking off a hip complaint.
Wales XV: To be confirmed
Ireland XV: To be confirmed
HEAD TO HEAD
BETTING ODDS (provided by 888Sport)
Wales to win at 13/10
Draw at 18/1
Ireland to win at 16/25
Odds correct as of 4pm March 7. Click here to place a bet.