The Dragons went all the way to the semi-finals at Euro 2016, losing out to eventual winners Portugal.
While the Welsh may not be at the peak of their powers, the likes of Gareth Bale, Aaron Ramsey and Dan James still possess enough quality to cause problems for most sides - but they need to get points on the board this weekend.
The Swiss are in the same position as Wales in that a bad defeat here could mean curtains for their Group A hopes, with Turkey and Italy completing a well-balanced group.
Date, kick-off time and venue
Wales vs Switzerland is scheduled for a 2pm BST kick-off on Saturday, June 12, 2021.
The match will be held at Baku Olympic Stadium in Azerbaijan.
Where to watch Wales vs Switzerland
TV channel: The match will be televised live on BBC One and via Welsh TV channel S4C for free.
Live stream: UK viewers will be able to watch the match online via the BBC iPlayer.
Wales vs Switzerland team news
Wales starting XI: Ward; Roberts, Mepham, Rodon, Davies; Allen, Morrell; Bale, Ramsey, James; Moore
Switzerland starting XI: Sommer; Mbabu, Elvedi, Akanji, Schar, Rodríguez; Freuler, Xhaka; Shaqiri; Seferovic, Embolo
Goalkeepers: Wayne Hennessey, Danny Ward, Adam Davies
Defenders: Connor Roberts, Neco Williams, Chris Gunter, Joe Rodon, Ethan Ampadu, Chris Mepham, Ben Cabango, Ben Davies, Rhys Norrington-Davies, Tom Lockyer
Midfielders: Joe Allen, Joe Morrell, Matthew Smith, Jonny Williams, Aaron Ramsey, Dylan Levitt, Rubin Colwill, Harry Wilson
Forwards: Daniel James, David Brooks, Tyler Roberts, Gareth Bale, Kieffer Moore
Goalkeepers: Yann Sommer, Jonas Omlin, Yvon Mvogo
Defenders: Fabian Schar, Ricardo Rodriguez, Manuel Akanji, Nico Elvedi, Jordan Lotomba, Becir Omeragic, Silvan Widmer, Loris Benito, Kevin Mbabu, Eray Comert
Midfielders: Granit Xhaka, Xherdan Shaqiri, Steven Zuber, Denis Zakaria, Remo Freuler, Edimilson Fernandes, Djibril Sow
Forwards: Haris Seferovic, Admir Mehmedi, Breel Embolo, Mario Gavranovic, Ruben Vargas, Christian Fassnacht
Wales vs Switzerland prediction
This could be a tight game decided by the odd goal, but both sides would probably accept a point to kick things off.
Wales 1-1 Switzerland
Head to head (h2h) history and results
Wales wins: 2
Switzerland wins: 5
Betting odds and tips
Wales to win: 27/10
Switzerland to win: 6/5
Odds via 888sport (subject to change). Click here to find out more.