Frank Lampard's side threw away a two-goal lead and conceded a last minute equaliser in last weekend's 3-3 draw at home to Southampton and were also held to a 0-0 draw by Sevilla in their opening Champions League group stage match in midweek.
United, meanwhile, arrive on a high after secured a terrific win away at PSG in their Champions League outing, having thumped Newcastle 4-1 in the league last weekend.
Lampard has painful memories of this fixture last season, which was his first in the Premier League as a manager, as his team were hammered 4-0 by a rampant United.
TV Channel: The match will be shown live on Sky Sports' Premier League and Main Event channels, and is available via Now TV. Coverage begins at 5pm, with kick-off at 5:30pm.
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League.
Terms: Min £10 Same Game Multi bet on any EPL match this Fri - Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.