David Moyes' side have lost all three matches since the international break, and the frustration among the club's supporters was clear during the weekend defeat to Everton so must now find a way to quickly bounce back.
It will not be easy against an Arsenal side who are unbeaten domestically this season, and who go into this match having swept Sheffield United aside on Saturday in comprehensive fashion.
The Gunners edged past Brentford to reach this stage of the competition, while West Ham battled to a similarly narrow win over Lincoln.
Date, kick-off time and venue
West Ham vs Arsenal is scheduled for a 7.30pm GMT kick-off tonight, Wednesday, November 1, 2023.
The match will take place at the London Stadium.
Where to watch West Ham vs Arsenal
TV channel: The game will be broadcast on Sky Sports Main Event, Sky Sports Football and Sky Sports Ultra HDR. Coverage starts at 7pm GMT.
Live stream: Subscribers will be able to watch on a live stream via the Sky Go app.
Live blog: However, you can follow all the action tonight via Standard Sport’s live blog, with expert analysis from Malik Ouzia and Simon Collings at the ground.
West Ham vs Arsenal team news
West Ham XI: Fabianski; Coufal, Mavropanos, Aguerd, Emerson, Alvarez, Soucek, Kudus, Paqueta, Benrahma, Bowen
Subs: Areola, Cresswell, Ward-Prowse, Fornals, Antonio, Cornet, Ings, Ogbonna, Kehrer
Arsenal XI: Ramsdale; White, Gabriel, Kiwior, Zinchenko; Jorginho, Vieira, Havertz; Nelson, Nketiah, Trossard
Subs: Hein, Cedric, Tomiyasu, Saliba, Rice, Elneny, Saka, Odegaard, Martinelli
West Ham vs Arsenal prediction
There has been little to get excited about for West Ham fans recently, with their side playing poor football and struggling to build on the early-season momentum they had.
There is still a sense that Arsenal are not quite firing on all cylinders, but they have the depth now to name a strong side even when making a number of changes and the Gunners can be expected to get the job done comfortably enough here.
Arsenal to win, 3-1.
Head to head (h2h) history and results
West Ham have beaten Arsenal just twice since 2007, with the Gunners unbeaten in the last eight matches between the two sides.
West Ham wins: 35
Arsenal wins: 72
West Ham vs Arsenal match odds
West Ham to win: 15/8
Arsenal to win: 11/10
Odds via Betfair (subject to change).