The Hammers have picked up where they left off last season and on Thursday night made it two wins from two in the Europa League group stage as they beat Rapid Vienna.
Brentford, meanwhile, have taken to life in the top flight like ducks to water and picked up their latest showpiece result in the form of a thrilling 3-3 draw with Liverpool last weekend.
Date, kick-off time and venue
West Ham vs Brentford is scheduled for an 2pm BST kick-off on Sunday, October 3, 2021.
Where to watch West Ham vs Brentford
This match will not be televised live in the UK.
West Ham vs Brentford lineups and team news
West Ham XI: Fabianski, Coufal, Zouma, Ogbonna, Cresswell, Soucek, Rice, Bowen, Fornals, Benrahma, Antonio
Subs: Yarmolenko, Lanzini, Vlasic, Areola, Dawson, Diop, Masuaku, Johnson, Kral
Brentford XI: Raya, Jorgensen, Jansson, Pinnock, Canos, Baptiste, Norgaard, Janelt, Henry, Mbeumo, Toney
Subs: Goode, Jensen, Forss, Wissa, Ghoddos, Onyeka, Bidstrup, Roerslev, Fernandez
West Ham vs Brentford prediction
West Ham have been superb so far this season and go into the game as favourites despite Brentford already having shown their ability to mix it with the best.
However, you wonder if their Thursday night escapades may prove something of a leveller, with the Bees having had a full week off since drawing with Liverpool.
West Ham 1-1 Brentford
Head to head (h2h) history and results
This will be the first Premier League meeting between the two sides.
Betting odds and tips
West Ham to win: 20/23
Brentford to win: 18/5
Odds via Betfair (subject to change). Click here to find out more.