Conte needs 29 points from the Blues' remaining 12 games to be sure of lifting the trophy in his first season in England.
Tottenham's victory over Everton on Sunday closed the gap to seven points, but another Chelsea victory tonight will move them closer to the title.
Chelsea head to east London to take on Slaven Bilic's Hammers having lost a tempestuous EFL Cup clash there earlier this season as both sets of supporters clashed in the stands at the end of the game.
All eyes will be on the match to ensure a repeat of the violence is avoided, while Conte will also be hoping for a better result on the pitch this time around as he hunts the title.
Scroll down for Standard Sport's comprehensive preview....
West Ham host Chelsea at London Stadium with kick-off scheduled for 8pm on Monday, March 6.
The match will be televised live on Sky Sports 1. Alternatively, you can follow all the build-up and action from 7pm with Standard Sport’s London Football live blog. Enter your email address below to be informed when coverage begins.
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Andy Carroll is set to replace Michail Antonio in the Hammers' squad.
Striker Carroll is fit after missing the last two games with a groin injury but winger Antonio is suspended following his red card at Watford last weekend.
Diafra Sakho (back) and Angelo Ogbonna (knee) are the only injury absentees.
Eden Hazard is expected to be fit for Chelsea after receiving a kick in training.
Antonio Conte expects the Belgium playmaker to be available at the London Stadium, with no other injury concerns for the league leaders.
West Ham starting XI: Randolph, Byram, Fonte, Reid, Cresswell, Noble, Obiang, Feghouli, Snodgrass, Lanzini, Carroll
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Pedro, Costa, Hazard
BETTING ODDS (via 888 Sport)
- West Ham to win: 51/10
- Chelsea to win: 5/9
- Draw: 31/10
Click here to place a bet. Odds correct as of March 6 at 4:45pm.