Wednesday's 3-0 loss at Arsenal was a fifth defeat on the spin, the same run of form which saw the club drop out of England's top flight just six years ago.
The Hammers now sit just five points above the drop zone with seven matches left to play and face a Swans side who dropped into the bottom three after a crushing late loss to Tottenham
Scroll down for Standard Sport's comprehensive preview...
West Ham host Swansea City at the London Stadium, with kick-off scheduled for 3pm on Saturday, April 8.
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West Ham are hopeful Andy Carroll and Michail Antonio will be fit to face Swansea.
Striker Carroll went off during the 3-0 defeat at Arsenal with a groin problem and winger Antonio had to be replaced at half-time due to illness.
Defenders Aaron Cresswell, Winston Reid and Angelo Ogbonna and midfielder Pedro Obiang are out injured.
Provisional squad: Adrian, Randolph, Byram, Fonte, Collins, Sakho, Masuaku, Kouyate, Noble, Fernandes, Nordtveit, Snodgrass, Feghouli, Antonio, Lanzini, Ayew, Carroll, Fletcher, Calleri.
Swansea have several injury concerns for the relegation battle at London Stadium.
Top scorer Fernando Llorente could return after missing the last two games with an ankle problem, but Kyle Naughton is struggling with a hamstring injury sustained in the midweek defeat to Tottenham.
Midfielder Leroy Fer is likely to be deployed at right-back if Naughton misses out, while goalkeeper Lukasz Fabianski will be checked after he suffered a heavy collision in the closing stages against Spurs.
Provisional squad: Fabianski, Naughton, Fernandez, Mawson, Olsson, Cork, Carroll, Ki, Fer, Routledge, Sigurdsson, Llorente, Ayew, Nordfeldt, Kingsley, Amat, Van der Hoorn, Britton, Fulton, Montero, Narsingh, McBurnie, Borja, Roberts.
West Ham starting XI: Randolph; Byram, Fonte, Collins, Masuaku; Noble, Kouyate; Ayew, Antonio, Lanzini; Sakho
Swansea City starting XI: Fabianski; Naughton, Fernandez, Mawson, Olsson; Fer, Cork, Carroll; Routledge, Ayew, Sigurdsson
BETTING ODDS (via 888 Sport)
- West Ham to win: 53/50
- Swansea City to win: 13/5
- Draw: 51/20
Click here to place a bet. Odds correct as of April 8 at 11am.