Wednesday's 3-0 loss at Arsenal was a fifth defeat on the spin, the same run of form which saw the club drop out of England's top flight just six years ago.
The Hammers now sit just five points above the drop zone with seven matches left to play and face a Swans side who dropped into the bottom three after a crushing late loss to Tottenham
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West Ham host Swansea City at the London Stadium, with kick-off scheduled for 3pm on Saturday, April 8.
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West Ham's injury worries mounted against Arsenal, with Andy Carroll hobbling off with a groin concern. Michail Antonio returned ahead of schedule but lasted just 45 minutes of the 3-0 loss.
Diafra Sakho is back, however, having spent months on the sidelines.
Fernado Llorente remains a doubt for the Swans with an ankle injury despite hope of a return against Tottenham last time out. Jordan Ayew, however, impressed in the loss on Wednesday so will lead the line.
Lukasz Fabianki refused to be substituted in the loss, despite recommendations from doctors, and went on to concede three late goals. It remains to be seen if the goalkeeper suffered lasting damage to himself.
Question marks continue over Leon Britton's fitness. Nathan Dyer and Angel Rangel are certain to miss out.
West Ham starting XI: Randolph; Byram, Fonte, Collins, Masuaku; Noble, Kouyate; Ayew, Antonio, Lanzini; Sakho
Swansea City starting XI: Fabianski; Naughton, Fernandez, Mawson, Olsson; Fer, Cork, Carroll; Routledge, Ayew, Sigurdsson
BETTING ODDS (via 888 Sport)
- West Ham to win: 27/25
- Swansea City to win: 13/5
- Draw: 51/20
Click here to place a bet. Odds correct as of April 6 at 9.30pm.