Western govts back AstraZeneca vaccine as S. Africa halts rollout after shot falters against variant

·5-min read

Western governments rushed to offer support for the AstraZeneca Covid-19 vaccination after South Africa halted its roll-out when research showed it offered minimal protection against mild infection from a variant spreading there. Despite concerns, the lead investigator on the South African trial of the vaccine said he believed it had a major role to play in combating the virus.

The arrival of vaccines has given hope that scientists can tame a pandemic that has killed 2.3 million people worldwide. But the AstraZeneca vaccine has run into several setbacks, the latest on whether it provides enough protection against the more transmissible South African mutation.

Shabir Madhi from the University of the Witwatersrand in Johannesburg, who was the lead investigator on South Africa’s AstraZeneva vaccine trial, said he would begin rolling out the one million AstraZeneca doses already in the country immediately, since they have an expiry date in April and it would be reckless to waste them.

But if vaccines are less effective against new variants, they may need to be tweaked and people may need booster shots.

Watch: Covid-19 - South Africa halts AstraZeneca vaccinations

The World Health Organization and its Covax partners on Monday cautioned against dismissing AstraZeneca’s Covid vaccine with the WHO's emergencies director Michael Ryan saying it was vital to use the tools available now to save lives.

"The primary job of vaccines right now is to reduce hospitalisations and deaths, and right now... they are working to do that," he said.

"We may need better vaccines to do more than just stop deaths and hospitalisations."

But "in emergency management you have got to do what you can do now", he added.

South Africa announced its pause after researchers from the University of Witwatersrand and the University of Oxford found that the AstraZeneca vaccine provided only minimal protection against mild or moderate infection from the B.1.351 variant, now the dominant form of the virus in that country.

The research is not yet peer reviewed and did not provide data on older people most likely to die or need hospitalisation.

There was no data on whether the vaccine would prevent severe illness, and researchers said that was still possible.

"This study confirms that the pandemic coronavirus will find ways to continue to spread in vaccinated populations, as expected," said Andrew Pollard, chief investigator on the Oxford vaccine trial.

"But, taken with the promising results from other studies in South Africa using a similar viral vector, vaccines may continue to ease the toll on health care systems by preventing severe disease."

Serious infections

French Health Minister Olivier Véran voiced support for the AstraZeneca vaccine, arguing it provided sufficient protection against "nearly all the variants" of the virus.

German Health Minister Jens Spahn said current evidence suggests all three vaccines approved in Europe - which include AstraZeneca - provided effective protection against serious infections.

Britain and Australia urged calm, citing evidence that the vaccines prevented grave illness and death, while AstraZeneca said it believed its vaccine could protect against severe disease.

"We think that both the vaccines that we're currently using are effective in, as I say, in stopping serious disease and death," British Prime Minister Boris Johnson told reporters.

Britain also uses the Pfizer shot.

"We also think in particular in the case of the Oxford AstraZeneca vaccine that there's good evidence that it is stopping transmission, as well, I think 67% reduction in transmission."

Australia is expected to approve the use of the AstraZeneca vaccine within days and expressed confidence in it.

"There is currently no evidence to indicate a reduction in the effectiveness of either the AstraZeneca or Pfizer vaccines in preventing severe disease and death. That is the fundamental task, to protect the health," Health Minister Greg Hunt said.

But if vaccines do not work as effectively as hoped against new and emerging variants, then the world could be facing a much longer - and more expensive - battle against the virus than previously thought.

The AstraZeneca vaccine was the big hope for Africa as it is cheap and easy to store and transport. South Africa, which had hoped to roll out the AstraZeneca shot this month, is storing around one million doses it has received from the Serum Institute of India.

The B.1.351 variant dominant in South Africa, also known as 20I/501Y.V2, is also circulating in at least 40 other countries, including the United States. Other major variants include one first found in Britain, known as 20I/501Y.V1, and one found in Brazil known as P.1.

Austria warned against non-essential travel to its Alpine province of Tyrol because of an outbreak of the South African variant there. Cases were also detected north of Paris, forcing one school to close.

Watch: How does the AstraZeneca/Oxford vaccine work?

Vaccine shock

An analysis of infections by the South African variant showed there was only a 22 percent lower risk of developing mild-to-moderate Covid-19, more than 14 days after being vaccinated with the AstraZeneca shot, versus those given a placebo.

Protection against moderate-severe disease, hospitalisation or death could not be assessed in the study of around 2,000 volunteers who had a median age of 31, as the target population were at such low risk.

Professor Shabir Madhi, lead investigator on the AstraZeneca trial in South Africa, said the vaccine's similarity to another produced by Johnson & Johnson, which reduced severe disease by 85 percent, suggested it would still prevent serious illness or death.

"There's still some hope that the AstraZeneca vaccine might well perform as well as the Johnson & Johnson vaccine in a different age group demographic that I address of severe disease," he told BBC radio.

Sarah Gilbert, professor of vaccinology at the University of Oxford, said efforts were underway to develop a new generation of booster shot vaccines that will allow protection against emerging variants.

"This is the same issue that is faced by all of the vaccine developers, and we will continue to monitor the emergence of new variants that arise in readiness for a future strain change."

The WHO’s 15-member Strategic Advisory Group of Experts on Immunization (SAGE) is due to render its verdict on the AstraZeneca vaccine later this week.

(FRANCE 24 with REUTERS and AFP )