Set in Ancient Rome, the show, which is described as "a visceral and authentic family saga", will see the duo play Antigone and Livius, respectively.
It also stars Kasia Smutniak (Perfect Strangers) as Livius' daughter Livia Drusilla, who acts as the main character, as it explores her journey from a naïve young girl following the assassination of Julius Caesar to Rome's most powerful and influential Empress.
"Driven by a deep desire to avenge her father and secure power for her sons, Livia and her peers navigate their way through a brutal society by means of strategy, conspiracy, seduction and murder.
"She will soon discover that seizing power is not enough: you must be able to keep it when everyone else wants it," reads the official synopsis.
Enzo Cilenti (Free Fire) will be seen as Tiberius Claudius Nero, while Claire Forlani (Meet Joe Black) plays Claudia Octavia. Isabella Rossellini (Blue Velvet) makes an appearance, too, as antagonist Balbina.
Matthew McNulty (Misfits) as the future emperor Gaius, Christine Bottomley (The End of the F***ing World) as Scribonia and Ben Batt (Captain America: The First Avenger) as Agrippa round out the star-studded cast.
Created and written by Fortitude's Simon Burke, Ophelia's Claire McCarthy is on board as lead director.
Domina is set to premiere on Sky Atlantic sometime in May 2021.
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