Oxford University and AstraZeneca on Wednesday acknowledged a manufacturing error that is raising questions about preliminary results of their experimental Covid-19 vaccine. A statement describing the error came days after the company and the university described the shots as "highly effective" and made no mention of why some study participants didn't receive as much vaccine in the first of two shots as expected. In a surprise, the group of volunteers that got a lower dose seemed to be much better protected than the volunteers who got two full doses. In the low-dose group, AstraZeneca said, the vaccine appeared to be 90 per cent effective. In the group that got two full doses, the vaccine appeared to be 62 per cent effective. Combined, the drugmakers said the vaccine appeared to be 70 per cent effective. But the way in which the results were arrived at and reported by the companies has led to pointed questions from experts. The partial results announced on Monday are from large ongoing studies in the UK and Brazil designed to determine the optimal dose of vaccine, as well as examine safety and effectiveness. Multiple combinations and doses were tried in the volunteers. They were compared to others who were given a meningitis vaccine or a saline shot. Before they begin their research, scientists spell out all the steps they are taking, and how they will analyse the results. Any deviation from that protocol can put the results in question.
Five more federal executions are scheduled in the weeks before Joe Biden enters the White House
Police have launched a hate crime investigation.
Lorraine Stanley discusses the festive episodes.
TV star nicknamed The Boominator was a renowned Arsenal fan
China has suspended sales and storage of cold-chain and aquatic products at a Beijing market – Asia’s largest – linked to a summer outbreak, as authorities continue pushing a narrative that the coronavirus was imported from abroad. Refrigerated meat, seafood and other frozen products have all been tossed at Xinfadi market, located in a southern district of Beijing. Cold storage facilities at the market have also been disinfected and shut down, according to Chinese state media. For months, Chinese officials have blamed cluster outbreaks on coronavirus they say have been found on frozen food products imported from countries including the US, EU, New Zealand, Canada, India, Germany and Ecuador. Many of the countries, however, have said they’re unsure about China’s methodology in detecting the virus. But that hasn’t stopped Chinese authorities from rushing to test food products and the workers that handle them, as well as banning imports and disrupting global trade. The US has questioned whether the crackdown is indeed based in science, especially as many of the nations impacted are embroiled in diplomatic spats with Beijing. China often uses economic leverage to punish nations as bilateral tensions rise.
The money saving expert has shared his forecasts for Black Friday, including offers from Asos and Game
The Queen's royal Christmas will be a very different affair this year. Traditionally, the royal family descend en masse to the Sandringham estate for a festive stay with the monarch. The Queen and the Duke of Edinburgh, however, have a large family of four children and eight grandchildren, who are all nearly grown up, along with eight great-grandchildren.
Gemma, who took part in the BBC show in 2017, is also the girlfriend of Maisie’s dance partner Gorka Marquez.
EU threatens to pull out of Brexit talks if UK refuses to compromiseMichel Barnier says further negotiations would be pointless if UK does not change stance
John Cleese is once again asking questions about trans people and this man really needs to learn how to Google or talk to a trans person.
What's coming up on the wards?
These astonishing images show off the majesty of some of the world’s greatest landmarks in a whole new light.From skydivers over the Great Pyramids of Giza to a Welsh farmhouse, the pictures were all submitted for the 2020 Historic Photographer of the Year Awards.The awards called on photographers to capture “history all around us”, in the form of historical places and cultural sites around the globe.Astonishing images of civilisation’s most iconic landmarks, including the Taj Mahal, Pompeii and the Palace of Versailles are just some of the historical sites featured.But the overall winner out of thousands of entries in the worldwide competition was awarded to Michael Marsh, for his sombre picture of Brighton Palace Pier, captioned “standing in the full force of weather and time”.Entries were judged on composition, originality and technical proficiency alongside the story behind the submission and its historical impact.
This is one of the five key metrics the government is using to determine lockdown tiers.
The Scottish Parliament has voted for a second time to demand the government hand over legal advice about its unlawful investigation of Alex Salmond.
The Middle Eastern studies expert had been picked up at Tehran Airport while trying to leave the country after attending a conference. Mrs Zaghari-Ratcliffe has been detained in Iran since 2016 after being sentenced to five years in prison over allegations, which she denies, of plotting to overthrow the Iranian government.
An investigation has been launched after a woman said she sustained “life-changing injuries” after being bitten by a police dog at an illegal rave in Bristol, United Kingdom, on October 31, British media reported.Jessica Mae Andrews told The Independent that the dog had bitten her without warning as she was dancing at the event in Yate, just outside Bristol.“The dog came out of nowhere, grabbed me by the thigh and pulled me to the floor,” she told the newspaper in an interview published November 21. “After biting through my thigh, it let go then and started to maul me again – this time biting my calf and foot where it did the most damage,” Andrew said.Andrew was taken to hospital following the attack, where she was reported to have undergone reconstructive surgery involving skin and muscle grafts.The footage here shows the moments of the incident. Andrew is seen on the ground, surrounded by police, as a dog bites at her leg, and as a line of officers in riot gear faces toward the remaining revellers.Storyful is seeking comment from Avon and Somerset Police regarding the incident.The police service did release a statement about the rave on November 24, in which they said 12 people had been arrested and two organizers had been given £10,000 fixed penalty notices. The press release included body-worn camera footage from police as they entered the rave, and an appeal for help identifying people who were at the event.The statement included no mention of the incident involving Andrew and the police dog.At least 500 people were estimated to have accessed the premises by the time officers established a cordon, the statement said, adding that officers “were pelted with items, including bottles, as they dealt with the incident (…) and deserve credit for the courageous and professional manner in which they handled it.” Credit: Anonymous via Storyful
This was first published in The Telegraph's Brexit Bulletin newsletter. For more analysis from The Telegraph's unrivalled Brexit team, sign up to the Brexit Bulletin here and we'll post it to your inbox every Monday, Wednesday and Friday. The European Research Group (ERG) of Conservative MPs – which did so much last year to oppose Theresa May's Brexit deal and so ushered in the premiership of Boris Johnson – has maintained a Trappist vow of silence while the Brexit talks have been ongoing. The only eruption was over the Internal Markets Bill, which breaks the law in a "specific and limited way" if a trade agreement is not agreed with the European Union by the end of next month. I texted several well-known members of the group last night to ask what the ERG was planning next. If I had done that 18 months ago, my phone would have been pinging with splenetic invective about Mrs May's handling of the Brexit talks. But this time – not a peep. Then a source got in touch. The truth is that the ERG is biding its time as they know there will almost certainly have to be a vote on the new deal before it comes into force, they said. Ministers can ratify any UK-EU treaty (which is what the final agreement would be) under the Constitutional Reform and Governance Act 2010 (CRAG), which requires it to be laid before Parliament. It then automatically becomes law if MPs don’t vote against it within 21 days of the date of laying. However, the Government is under no obligation to call a vote on any treaty – it removed its previous commitment to hold a vote on the final UK-EU treaty from the European Union (Withdrawal Agreement) Act 2020, which was passed in January.
New plans for couple’s New Jersey property include ‘relocated helicopter’, four new pickleball courts, and spa and yoga complex
Here are the latest COVID-19 infection rates across England.