The ten group runners-up will face off with two Nations League teams next year.
Here, we run through how the Uefa play-offs will pan out.
When is the draw for the play-offs?
The play-offs will be drawn on Friday, November 26, 2021. The draw will be held in Zurich and begins at 4pm GMT.
The draw will set out the semi-final clashes before determining the host of the final in each of the three paths.
How can I watch the play-off draw?
The draw will be streamed live on FIFA’s YouTube channel.
Who is involved in the play-offs and who is seeded?
Seeded: Portugal, Scotland, Italy, Russia, Sweden, Wales
Unseeded: Turkey, Poland, North Macedonia, Ukraine, Austria, Czech Republic
The six runners-up who accrued the most points in qualification are seeded, with the remaining four teams and two Nations League teams unseeded.
Ukraine are unseeded, however Uefa will not allow them to be drawn against seeded Russia for political reasons.
Which Nations League teams are involved?
The group winners of the 2020/21 Nations League have been ranked based on their performance, with the top two teams not finishing inside the top two of their qualification group entering the play-offs.
Austria are assured of their place via this route after finishing as the sixth-highest Nations League group winner but third in qualification Group F.
Wales secured second in Group E with a draw against Belgium earlier this month, with Czech Republic already safe in the knowledge that even in third-place they could fall back on their Nations League ranking, of seventh, to reach the play-offs.
France, Spain, Italy and Belgium were the top-four Nations League group winners but all automatically qualified for the World Cup or the play-offs.
How will the play-offs work?
Three paths of four teams will each play out two semi-finals and a final. The seeded team will host the semi-final with the host of each final decided as part of today’s draw.
All ties will be played over a single leg before extra-time and penalties, if required.
Player suspensions from the group stage will be carried over into the play-offs.
When are the play-offs?
The semi-finals will be played on the evening of Thursday, March 24 and Friday, March 25, 2021.
The finals are scheduled for Monday, March 28 and Tuesday, March 29, 2021.