The Welsh winger picked up an ankle injury in the 3-1 win away to Unionistas de Salamanca in the previous round last week and although he trained normally on Tuesday, he has been kept in reserve ahead of Saturday’s derby at home to Atletico in LaLiga.
Hazard has been sidelined with an ankle problem of his own since late November and is the final stages of his recovery, but will not feature in Zaragoza and is expected to miss the Madrid derby as well.
Marco Asensio is also still out, although the Spanish international is back in training as he recovers from an anterior cruciate ligament injury sustained in pre-season.
Casemiro, Isco and Eder Militao have all been rested for the visit to La Romareda, while there is no place in the squad for Mariano.
Real Zaragoza possible XI: Alvarez; Vigaray, Atienza, Grippo, Nieto; Eguaras, Raul Guti, James, Kagawa; Luis Suarez, Raphael Dwamena
Real Madrid possible XI: Courtois; Carvajal, Nacho, Ramos, Marcelo; Valverde, Kroos, James; Rodrygo, Benzema, Vinicius Junior