Brandreth is a former MP and current 'One Show' reporter.
Channel 4 continues to search for a permanent replacement for Anne Robinson.
Vorderman previously appeared on the show between 1985 and 2008.
As Anne Robinson bows out, we look at who else has presided over the quiz show.
The radio DJ has guest hosted the quiz show before when Nick Hewer was shielding during the coronavirus pandemic.
The presenter says she isn't planning to take on any more TV work.
The presenter hosted the series for several years.
Vorderman previously co-hosted the Channel 4 quiz show for 26 years.
The TV presenter took over as host of the Channel 4 show in June 2021, but is ready to step down.
The 'Countdown' star admitted the plight of women in Ukraine weighed heavily on her mind.
Carol Vorderman has opened up about how a family rift kept her from visiting her native Wales for years
The Countdown presenter and her dancer husband revealed their second daughter was born on Bonfire Night, 15 days after her due date.
The TV star was in shock.
The star had a go at cryotherapy, which involves exposing the skin to extremely cold temperatures.
The star asked her fans what she should wear to an awards show.
The star spilled the beans on Twitter.
A spokesperson for the Channel 4 gameshow said the word had been included in "an error of judgement".
The homophobic slur was read out by a contestant as a seven-letter answer to the word quiz, for which he was awarded the points.
Anne Robinson has again made controversial comments about sexual harassment in office environments.
Can you recall anything other than England's win and THAT image of Matt Hancock? Take this quiz to test your memory.
It comes as the 76-year-old is set to host her first episode of 'Countdown' on Monday.
The new 'Countdown' host does not want to change the way she speaks for fear of offending people.
The TV presenter is due to join the show at the end of June.
The dancer is concerned about his wife's health during pregnancy.
The 35-year-old TV presenter used a 'Countdown' conundrum to reveal her happy news.