The journalist was a guest on Piers Morgan Uncensored, where he discussed Maitlis' comments about Dominic Cummings.
'The Wrestler' star dismissed Tom Cruise's career, saying he has played the same part for 35 years.
Osbourne said it's "very important" to her to have returned to television.
Viewing figures for Piers Morgan's new show, 'Piers Morgan Uncensored', have dropped by a third after one night.
'Piers Morgan Uncensored' is set to be the flagship show of the new channel from Rupert Murdoch's News UK.