The three puppies were found suffering from sarcoptic mange – a parasite that causes intense itching and leads to loss of fur.
The animal charity said the show had incidences where animals had been killed 'for no other purpose than entertainment'.
Charity pleads for animal-lovers to protect their pets as the UK faces the hottest day of the year so far.
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The RSPCA and police have called on anyone with information about the alleged incident to come forward.
The 13 royal pythons were dumped behind Farringdon Fire Station in Sunderland, Tyne and Wear, inside pillowcases.
TJ Gregory and Sarah Henniker left the two pugs Millie and Tito inside a tent for eight hours when temperatures had risen to 34C.
The video footage shows RSPCA rescuers chasing the fox around the sewage treatment works in Barrow, Cumbria.
Shocked RSPCA inspectors found Smiler the American Bulldog barely conscious in a pool of blood in a bath in Keighley, West Yorkshire.
Clive Elliott, 40, was convicted in his absence at Swindon Magistrates' Court after the greyhounds were found starving, with the body of one stuffed in a freezer.
Two adorable cockapoo puppies almost died of starvation before they were miraculously discovered and nursed back to health.
Their mange was so bad they are covered in bald patches and were even more vulnerable in the cold weather.