Reuniting Superbad duo Emma Stone and Jonah Hill 11 years after the hit movie, Maniac tells the stories of Annie Landsberg (Stone) and Owen Milgrim (Hill) as their worlds collide in the late stages of a mystery pharmaceutical trial.
The 10-parter, directed by new James Bond director Cary Joji Fukunaga, is what is known as a limited series, meaning the predetermined number of episodes tell the story from start to finish.
Here is everything you need to know:
What is Maniac about?
The series follows Annie and Owen as they take part in a groundbreaking drug trial, determined to “repair their mind” and have their lives turn out the way they want them to.
They - and 10 others – are drawn to the trial by Dr James K. Mantleray, who promises that the pill he has invented can help them achieve what they want to, with Annie wanting to escape her failed, broken and strained relationships and Owen, running from his schizophrenia diagnosis.
Who stars in Maniac?
Superbad pals, Stone and Hill, who played Seth and Jules in the 2007 movie, portray the two central characters and take up the majority of the time on screen.
Justin Theroux stars as Dr Mantleray, the man promising perfection, while Sally Field is Greta Mantleray.
Girls star Jemima Kirke and actress Julia Garner are also among the cast.
How can I watch Maniac?
All 10 episodes – which range from 23 minutes to 44 minutes – land on Netflix on Friday, September 21. UK subscribers can expect to see the series from 8am.