Edgaras Cepura, a 37-year-old software engineer, died on May 18 after being struck by a lorry on the A206 by the Woolwich Road roundabout.
Heathrow worker Oliver Speke, 46, collided with a lorry outside the Old Royal Naval College in Greenwich, also on the A206 Romney Road, and died in hospital two days later on May 11.
Outspoken campaign group Stop Killing Cyclists will take to the street outside Woolwich Town Hall – not far from the road where the tragic collisions occurred – to stage a “die in” in response to the deaths.
Protesters will lie in the road with their bikes in order to highlight the dangers faced on the streets of London.
The protest is planned for the evening of Wednesday June 7.
Campaigners taking part are calling for the proposed Cycle Superhighway 4 from Tower Bridge to be extended along the A206 to Woolwich.
The area of road that runs from the Cutty Sark to the Blackwall Tunnel flyover had initially been part of initial CS4 plans but was dropped from the route, which is out for consultation.
Their demands also include enforcing technology that uses carefully-placed cameras to show lorry drivers if anyone is in their blind spot, and introducing emergency safety measures at Woolwich Road Roundabout junction.
STK Co-founder Donnachadh McCarthy said the “peaceful” protest would be held in response to the “horrific deaths”, adding: “Month after month pedestrians and people cycling are suffering horrific deaths by blindly driven HGVs.
“It is time the mayor made CCTV mandatory for trucks sharing our streets with people walking and cycling.”
Co-organiser Alex Raha added that the council was “delaying the extension of the protected cycle-highway CS4 by up to 8 years”, accusing them of being “one of the most anti-cycling councils in London”.
But a Greenwich council spokesman said it was lobbying Transport for London to “ensure delivery of the full CS4 route to Woolwich as swiftly as possible”.
Nigel Hardy, head of programme sponsorship for surface transport at TfL, said it will work closely with the council “on our plans for a new cycle route between Greenwich and Woolwich.”