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But Verstappen can also crown himself world champion if things go his way, so it promises to be a crucial race in deciding the title.
But will it be Verstappen or Hamilton that come out on top in Saudi?
Here is everything you need to know about the race.
The race will start at 5.30pm GMT on 5 December at the Jeddah Corniche Circuit in Saudi Arabia.
The race will be broadcast live in the UK, with coverage beginning at 4pm on Sky Sports F1 and from 5pm on Sky Sports Main Event.
If you’re not a Sky customer, you can grab a NOWTV Day Pass here to watch without a subscription.
1. Verstappen - 351.5
2. Hamilton - 343.5
3. Bottas - 203
4. Perez - 190
5. Norris - 153
6. Leclerc - 152
7. Sainz - 145.5
8. Ricciardo - 105
9. Gasly - 92
10. Alonso - 77
What Hamilton has said
Speaking about the final two races of the season, seven-time champion Hamilton said: “It’s different in one sense because we’ve got two incredibly close teams. It’s different because as a team we’re fighting for uncharted territory. No-one has ever won eight titles, team or driver, so that’s quite fresh and new.
“And then on the other side, I’m more relaxed than I’ve ever been because I’ve been around a long time. It’s not my first.
“I remember how I was [with] my first championship, and even my second and my third, the sleepless nights and all those sorts of things. I’m [now] a lot more sure of myself and just applying myself better than ever before.
“I know I can’t change anything from the past, but all I can do is prepare the best I can for what’s up ahead of me, and I 100% know I have.”
Lewis Hamilton - 6/11
Max Verstappen - 13/5
Valtteri Bottas - 12/1
Sergio Perez - 33/1
Mercedes have clearly shown over the last two races that they have the superior pace over Red Bull. Both the Brazil and Qatar Grands Prix showed that Verstappen is up against it if he is to hold off a late-season charge from Hamilton. And, with a thrilling final race in Abu Dhabi on the cards, the Brit could level things up or even nudge in front ahead of next weekend.