This week's festival will be the first Glastonbury since 2019 as the 2020 and 2021 events were cancelled due to the Covid-19 pandemic.
The Pyramid Stage will be headlined by Billie Eilish, Paul McCartney on Saturday and Kendrick Lamar on Sunday.
Leading up to the Eilish on the Main Stage will be Sam Fender, Robert Plant and Alison Krauss, Wolf Alice and Crowded House.
Headlining the Other Stage on the Friday night are rockers Foals who will be preceded by St Vincent and IDLES with sets from The Libertines and Kae Tempest also scheduled for earlier in the day.
The West Holts Stage will be headlined by Little Simz whereas Primal Scream will top the John Peel Stage at the same time.
Phoebe Bridgers and Sigrid and The Jesus and the Mary Chain are scheduled to play before Primal Scream.
Before McCartney's much-anticipated headline set, fans can see Noel Gallagher's High Flying Birds in what is the former Oasis songwriter's first solo appearance at the festival.
Also on the Main Stage before McCartney are Haim, AJ Tracey and Joy Crookes.
Headlining the Other Stage will be Megan Thee Stallion with performances from Burna Boy, Olivia Rodrigo and Glass Animals set to take place earlier in the evening.
Roisin Murphy is set to headline the West Holts on the Saturday with Leon Bridges, Celeste and Yves Tumor also set to appear.
The John Peel Stage will be topped by a returning Jamie T and he will be joined earlier in the day by Ghetts, Self-Esteem, Holly Humberstone and Yungblud.
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With Kendrick Lamar being the headliner on the Sunday, the likes of Lorde, Diana Ross, Elbow and Herbie Hancock will be taking to the Main Stage earlier in the day.
The Pet Shop Boys will top Sunday's Other Stage with the likes of Years & Years, Kacey Musgraves and Fontaines DC to also perform.
Pop superstar Charli XCX will also headline the John Peel Stage on the Sunday.
Other notable acts to perform at the festival include the original lineup of the Sugababes, Mercury Prize winner Arlo Parks, performance poet John Cooper Clarke, pop band McFly and actor Riz Ahmed.
Glastonbury takes place between 22 and 26 June at Worthy Farm in Somerset.
Watch below: Sir Paul McCartney and Kendrick Lamar confirmed to headline Glastonbury.