The actor, 55, is competing on the BBC ballroom show with pro partner Karen Hauer, and Love Actually star Thompson has been spotted cheering him on in the audience.
But Wise admitted on ITV’s Lorraine that Thompson is getting increasingly nervous about his performances.
“Em’s become so anxious that she feels she has to be there every Saturday in the studio," he said.
“So she is going to camouflage herself and pretend to be someone on the sound department I think.”
The Peep Show star, who underwent open heart surgery two years ago, announced this week that he was withdrawing from the competition due to his health.
Webb, who was paired with pro Dianne Buswell, said that he had been advised to quit after he had started to feel symptoms while he was training for the show.
Wise said he had messaged Webb as soon as he heard that he was leaving the dancefloor.
"Bless him, I wrote to him yesterday evening when he sent us all this beautiful note,” he said.
"I said, 'Look mate, you are brave twice. You are so brave to have done this in the first place, and then doubly brave to have said actually I have to stop now'.
"I mean, that takes immense courage."
Watch: Emma Thompson encouraged Greg Wise to sign up for Strictly