The 39-year-old, who rose to fame in the E! TV show, told fans it will come to an end after the airing of the 20th season in 2021.
The reality series began in 2007 and catapulted her family to global stardom.
Video: Kim Kardashian West announces end of family’s reality TV show after 20 seasons
Kardashian West wrote on Instagram: “It is with heavy hearts that we’ve made the difficult decision as a family to say goodbye to Keeping Up With the Kardashians.
“After what will be 14 years, 20 seasons, hundreds of episodes and numerous spin-off shows, we are beyond grateful to all of you who’ve watched us for all of these years – through the good times, the bad times, the happiness, the tears, and the many relationships and children. We’ll forever cherish the wonderful memories and countless people we’ve met along the way.
“Thank you to the thousands of individuals and businesses that have been a part of this experience and, most importantly, a very special thank you to Ryan Seacrest for believing in us, E! for being our partner, and our production team at Bunim/Murray, who’ve spent countless hours documenting our lives.
“Our last season will air early next year in 2021.”
Keeping Up With The Kardashians centres around Kim’s family life with her sisters Kourtney and Khloe, and her half-sisters Kendall and Kylie Jenner.
The show also stars their ambitious manager mother Kris Jenner, Jenner’s ex-husband Caitlyn – a former Olympic athlete who came out as a transgender woman in 2015 – and Kim’s brother Rob Kardashian.
Kim added: “Without Keeping Up with The Kardashians, I wouldn’t be where I am today. I am so incredibly grateful to everyone who has watched and supported me and my family these past 14 incredible years. This show made us who we are and I will be forever in debt to everyone who played a role in shaping our careers and changing our lives forever.”
Khloe, 36, tweeted: “I love you guys so much!!! Thank you for everything!!! The emotions are overflowing today change is tough but sometimes needed. I can’t express how much I love and appreciate you guys.”
Kourtney, 41, tweeted any early throwback video of the young Kardashian sisters and “momager” Kris, 64, promoting their new show back in 2007.
A spokesperson for E! said in a statement to CNN: "While it has been an absolute privilege and we will miss them wholeheartedly, we respect the family's decision to live their lives without our cameras."
Kris has shared Kim’s statement on her Twitter page but Kylie and Kendall, 24, have not yet commented on the announcement.
The show also made celebrities of Kourtney's ex-boyfriend Scott Disick, Kim's ex-husband Kris Humphries and Khloe's ex-husband Lamar Odom.
The daughter of lawyer Robert Kardashian, who represented OJ Simpson during his murder trial and died in 2003, Kim first appeared on TV as a guest in friend Paris Hilton’s reality show The Simple Life between 2003 and 2006.
When a sex tape Kim made with her ex-boyfriend Ray J was leaked in 2007 she skyrocketed to fame and landed her own TV show.
As KUWTK ran the rest of the family also became celebrities, with her youngest sister Kylie Jenner being declared the world’s youngest self-made billionaire at the age of 21 in 2019 thanks to her successful cosmetics line.
Kim is now married to rapper Kanye West, with whom she has four children: North, 7, Saint, 4, Chicago, 2, and Psalm, 1.