Joe and Katherine's Bargain Holidays sees the friends seek out the best holiday deals and cheapest things to enjoy while away in both the UK and further afield.
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While After Life star Wilkinson is known for his love of a bargain, Ryan is much keener on a luxury getaway - but she will find out whether it is possible to enjoy champagne tastes on a lemonade budget.
They'll be looking for how to bag a bargain rental, haggle like a pro and make the most of the free breakfast buffet in the six-part series that shows how to have a fantastic holiday for next to nothing.
Couples' retreats, weekends away with friends, and family holidays are all covered in undiscovered resorts where they'll road test the best value for money activities.
Wilkinson said: “If pushed on it, I’d have to say my three favourite words are ‘bargain’, ‘holiday’ and ‘voucher’ (and ‘large vacuumed packed portable food bags…’). This series gets under the skin of all three.
"We’re going to uncover the biggest bargain holidays in the world and we’re going to have some fun doing it! (And some tears, I well up at the drop of a hat).”
Ryan said: “Three of my favourite words are ‘cocktails’, ‘Maldives’ and ‘helicopter’. This series is really going to test my friendship with Joe.”
Canadian comedian Ryan recently launched fly-on-the-wall series Backstage with Katherine Ryan for Prime Video, which lifts the lid on what goes on as stand-up comedians wait to go on stage.
It features her fellow stand ups Jimmy Carr, Rosie Jones, Seann Walsh, Russell Kane, Rob Beckett, Tom Allen and Sarah Millican, as well as Frankie Boyle, Sara Pascoe, Jo Brand, Joel Dommett, Nish Kumar, Judi Love and Sue Perkins.
She said of convincing the comedians to take part: “I think that if you had cancellable personality traits you probably wouldn’t have agreed to come on and everyone forgot the cameras were there after only a few minutes.”
Watch: Katherine Ryan thanks and defends Jimmy Carr at National Comedy Awards