Charles journeyed overnight from Ayr in Scotland, close to where his 18th-century property Dumfries House, part of The Prince’s Foundation, is based.
A group of local dignitaries were waiting to greet the King, who looked relaxed as he stepped from the locomotive.
The civic line-up included High Sheriff of Greater Manchester Lorraine Worsley-Carter, Greater Manchester Police Chief Constable Stephen Watson and Manchester Mayor Andy Burnham.
Queen Victoria was the first monarch to travel by train, leaving Slough at noon on June 13, 1842, and travelling to London’s Paddington Station.
Victoria had been persuaded on board by Prince Albert, a veteran of rail travel fascinated by the new technology.
Since the Victorian era, the royal family has enjoyed its own train, with the present royal carriages coming into service for the Queen’s Silver Jubilee in 1977.