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They lost 1-0 to Aston Villa at home last weekend and can ill-afford another slip-up.
Everton are level with United on 13 points after a strong start under Rafa Benitez and saw off Norwich last weekend thanks to goals from Andros Townsend and Abdoulaye Doucoure.
Date, kick-off time and venue
Manchester United vs Everton is scheduled for an 12:30pm BST kick-off at Old Trafford on Saturday.
Where to watch Manchester United vs Everton
TV channel: Saturday’s match will be televised on BT Sport 1, coverage starting at 11:30am.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app..
Manchester United vs Everton team news
Luke Shaw is an injury doubt for Manchester United. Shaw missed the 2-1 Champions League win over Villarreal through a combination of illness and injury and Ole Gunnar Solskjaer is not yet sure whether the left-back will be available.
If Shaw does not make, Alex Telles will continue at left-back after scoring against Villarreal.
Aaron Wan-Bissaka is available after serving a European suspension in midweek.
Marcus Rashford has returned to training for the first time since shoulder surgery, although the England international is not yet match fit and this game will come too soon for him.
Harry Maguire remains sidelined.
Manchester United vs Everton prediction
The feelgood factor around United was in danger of seeping away before that 95th-minute Ronaldo winner on Wednesday. They have looked poor in recent weeks but, while Everton will make life difficult for them, they should have enough to edge it.
United 2-1 Everton
Premier League head to head (h2h) history and results
United wins: 37
Everton wins: 9
Last meeting: Manchester United 3-3 Everton (06/02/2021)
Betting odds and tips
United to win: 40/85
Everton to win: 6/1
Odds via Betfair (subject to change). Click here to find out more.