United suffered back-to-back League defeats to spark talk of a club in crisis, but the Red Devils have won their last three matches - including Wednesday's 3-0 Champions League victory over Young Boys - to steady the ship.
But while United look to be back on track, they face a Wolves side full of confidence after a positive start to the campaign, and Nuno Espirito Santo - touted in recent weeks as a potential future United manager - will want to get one over on compatriot Jose Mourinho in his own back yard.
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TV, online and live stream coverage
The match will not be televised live in the UK.
Fortunately, you can follow all the action with Standard Sport's LIVE match blog, with analysis from James Robson at Old Trafford.
For Man United ticket information, click here for the club’s website.
Betting tips via Betfair | UK users only | Subject to change
- Man Utd to win 1-0: 11/2
- Wolves to win 2-1: 16/1
- Lukaku to score first: 16/5
- Pogba to score 2 or more: 14/1
Click here to find the latest match odds and place a bet.
Head to head
The two teams have met eight times in the Premier League, with United winning six of those and Wolves eight.
Wolves have never beaten United at Old Trafford in the League, and the last time these two sides met - during the 2011-12 season - United won 4-1 at home and 5-0 away.
Man Utd XI: de Gea, Valencia, Smalling, Lindelof, Shaw, Pogba, Fellaini, Fred, Lingard, Lukaku, Sanchez
Subs: Bailly, Mata, Martial, Andreas Pereira, Young, Romero, McTominay
Wolves XI: Rui Patricio, Bennett, Coady, Boly, Doherty, Joao Moutinho, Neves, Jonny, Helder Costa, Jota, Jimenez
Subs: Gibbs-White, John Ruddy, Saiss, Ruben Vinagre, Hause, Leo Bonatini, Traore
Referee: Kevin Friend (Leicestershire)