The 40-year-old professional dancer and star of the hit BBC show is married to Ukrainian national Evgenij Voznyuk, from the city of Kharviv, which is currently under siege by Russian troops.
Mabuse tweeted: "2020 we booked our flights to spend Easter in Kharkiv and return a day before my birthday, because of lockdown we cancelled the trip. 2021 we were still on lockdown! 2022 seems I will never see the town my husband was born. He wanted to show me his motherland! #Kharkiv. "
She added: "Hopefully one day!! Another day filled with horror! Please let this stop."
The Strictly star also highlighted the plight of Africans trying to flee Ukraine and reportedly being made to queue behind white refugees at the borders.
Sharing a clip of apparently segregated refugees she tweeted: "This is happening !!!! Can we talk about this !!!!!! Saving people according to their skin color!!!!! #AfricansinUkraine [sp]"
The South African-German dancer previously revealed how she was concerned for the safety of her parents-in-law and husband's family in Ukraine.
Mabuse previously tweeted: "It’s heartbreaking hearing my mother in law crying this morning, afraid and there absolutely nothing we can do! Just Sad honestly."
She later added: "Our parents have been told to go outside and to switch off water &gas ! They have no possibility to get to the polish border #Ukraine."
"We are [in] contact with them ! The spend more than half the day yesterday in the bunkers !!! In Kharkiv there are heavy battles so we can’t get to them! At the moment there is nothing we can do. We did try to get them earlier in Germany."
Mabuse married Voznyuk in 2017 and gave birth to their daughter the following year.
Watch: Craig Revel Horwood discusses Otsi Mabuse's exit from Strictly