The 57-year-old actor appeared on the first ever edition of Loose Women in 1999 and has had a second stint as a regular on the panel since 2013.
She said there are some co-presenters she is closer with than others and said the casting team and producers decide which panellists have better chemistry with each other.
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"The thing is, because we’re all women, people are all shocked that we get on," Sawalha said.
She added: "I remember when Judi Love first joined, she said to me: ‘Everyone keeps asking me what are they like?' I say: 'No honestly, they’re great, it’s a really great atmosphere’.
"We’re professional people. Four men on a show would never be asked if they get on. We’d never be asked if they’re alright after they’ve had [a few words]."
Sawalha said that being on Loose Women is "like any other job" in that there are some co-workers who she spends more time with, while others are just colleagues.
Elsewhere in the interview, Sawalha discussed her positive approach on Instagram and the apparent self-confidence with which she shares warts-and-all selfies.
She said: "I have huge health anxiety and spent most of my life hiding my body away and would never dream of wearing a bikini and I just got very sick and tired of it.
"This has been a long process over many years. It’s been really difficult to get where I am and I’m not body confident."
Sawalha rose to fame in the late 1990s for her role as Annie Palmer in EastEnders and also appeared on Casualty and The Bill.
Watch: Simon Amstell pokes fun at all-white Loose Women line-up