The actor is known for his TV role as the terrifying media mogul Logan Roy in drama Succession, where he unleashes a series of sweary tirades at his family and staff.
However, when he made his most recent appearance on BBC One's political debate show Question Time on Thursday, a suggestion that Truss should be allowed to make mistakes - despite her mini budget causing chaos in the financial markets - prompted a Logan-style outburst from a furious Cox.
“There is no human being alive that can say actually say they’ve never made a mistake”
“We’re not at a time where we can afford these kinds of mistakes”
Brian Cox and @theblackfarmer debate Liz Truss' leadership #bbcqt
Watch on @bbciplayer: https://t.co/98O3XH3BLS pic.twitter.com/0JQAlcVZ9R
— BBC Question Time (@bbcquestiontime) October 6, 2022
Earlier in the programme, Cox had already given his views on Truss, saying: “I just do not think she is the right person for the job. And I also don’t trust her… so, I ain’t a fan.”
But when the audience member said that Truss should be allowed to make mistakes and panellist Wilfred Emmanuel-Jones agreed, Cox's anger was ignited.
He banged the desk as he said: "We’re not at a time where we can afford these kinds of mistakes. They're being made time and time and time again, and it's got to stop."
Cox turned to former Chancellor of the Exchequer Nadhim Zahawi and told him: "We need some vision. This party has no vision."
Many other viewers agreed with Walker, with one person writing: "Best #bbcqt for ages! Brian Cox unleashing his inner Logan Roy was the highlight!! Terrifying."
Someone else added: "Brian Cox going full Logan Roy on #bbcqt is a thing of beauty. Thought someone was going to get told to 'F*** Off!'"
Another viewer tweeted: "Brian Cox channeling Logan Roy and I'm here for it. His outrage is our outrage."
Others felt Cox, who has appeared on Question Time before, was a brilliant addition to the panel chaired by Fiona Bruce which also included Lisa Nandy MP and Piers Morgan.
A viewer tweeted: "Can we have Brian Cox as the next PM please?"
Someone else added: "Brian Cox is full on ragin and rightly so."
Another person wrote: "Brian Cox absolutely destroys Liz Truss's failing government on live TV. The man is a national treasure."