England face South Africa in the Third Test of their tour as they bid to end a losing sequence stretching back six matches.
Danny Cipriani will make his first England start for a decade after being selected at fly-half.
Cipriani has ousted George Ford after playing 13 minutes as a second-half replacement for his rival in the series-conceding 23-12 defeat in Bloemfontein last weekend.
The tour to South Africa is his first appearance in an England squad under Eddie Jones and the Gloucester-bound playmaker has now impressed enough to be elevated into the starting XV.
It is only the third time Ford has been dropped since Jones took over in late 2015 and he is omitted from the 23 altogether.
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England team to play South Africa in the Third Test:
15-Elliot Daly, 14-Jonny May, 13-Henry Slade, 12-Owen Farrell (captain), 11-Mike Brown, 10-Danny Cipriani, 9-Ben Youngs, 8-Nathan Hughes, 7-Tom Curry, 6-Chris Robshaw, 5-Maro Itoje, 4-Joe Launchbury, 3-Kyle Sinckler, 2-Jamie George, 1-Joe Marler
Replacements: 16-Luke Cowan-Dickie, 17-Alec Hepburn, 18-Harry Williams, 19-Jonny Hill, 20-Mark Wilson, 21-Sam Simmonds, 22-Ben Spencer, 23-Denny Solomona.