The former US First Lady and Microsoft founder topped a YouGov survey of the most admired women and men on the planet.
The top 10 women also featured Oprah Winfrey and Angelina Jolie in second and third places respectively.
Last year, Jolie topped the poll with Michele Obama in second place.
In an eclectic list, the Queen came fourth, followed by Harry Potter actress Emma Watson and then Nobel Prize laureate, Malala Yousafzai.
`Also included in the top 10 are Hillary Clinton and Taylor Swift.
The You Gov poll also found that Michelle Obama’s husband, former US president Barack Obama, is the second most admired man in the world with Jackie Chan filling an unlikely top three for men.
Gates also topped the poll for men last year.
Vladimir Putin, Cristiano Ronaldo and Lionel Messi are also in the top 10.
The current US president, Donald Trump, though was back in 14th, one place behind technology entrepreneur Elon Musk.
For the British, the most admired woman was the Queen, Michelle Obama was second and Judi Dench in third place.
The most admired man in the UK was David Attenborough.
Barack Obama was second for Brits, with Prince Harry third.
The poll took in voted from people in 41 different countries and more than 42,000 people were interviewed to compile the list.
You Gov said that entertainers dominated the female list, with 12 of the most admired women being actresses, singers or TV presenters.
By contrast, the list of most admired men contains more people from political, business and sporting backgrounds.
Top 10 women
Queen Elizabeth II
Top 10 men