Dembele is only fit enough for a place on the Spurs bench, while Walker has to settle for a place among the substitutes as Trippier gets the nod.
Pochettino looks to have reverted to a back four despite having selected a back three in big games this season, while Eric Dier starts in midfield alongside Victor Wanyama as Harry Kane leads the line backed up by Dele Alli.
Spurs XI: Lloris, Trippier, Alderweireld, Vertonghen, Davies, Dier, Wanyama, Son, Eriksen, Dele Alli, Kane
Subs: Vorm, Walker, Wimmer, Dembele, Sissoko, Nkoudou, Janssen
Arsenal XI: Cech, Gabriel, Koscielny, Monreal, Oxlade-Chamberlain, Ramsey, Xhaka, Gibbs, Ozil, Sanchez, Giroud
Subs: Ospina, Holding, Bellerin, Coquelin, Iwobi, Walcott, Welbeck