The sixth series of the BBC police drama aired last year and there has been much speculation about whether it will come back for another run.
McClure – who is best known for playing DI Kate Fleming in the tense series – was quizzed about it on This Morning and revealed she would "love to go again".
"It would be weird if the day does come that we may never go again," she said.
"Not to work with Adrian (Dunbar), Martin (Compston) and Jed would be really weird.
"We've done it for 10 years."
"Insane really," she added.
So far there is no official word on a seventh series of the drama.
And last year Mercurio hinted to the Radio Times that things were still up in the air.
"We’re in a situation where it’s not entirely clear that there will be a seventh series,” he said.
"We would hope there could be. But we’re having to do our planning coming out of COVID, and a whole bunch of other things, around the idea that these things aren’t guaranteed at all now."
He said a lot of it came down to them “finding new stories to tell within that universe”.
In the meantime, McClure and Mercurio are teaming up again on new drama Trigger Point.
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