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Ant and Dec's Saturday Night Takeaway will return to ITV next week on Saturday 20 February.
It's the 17th series of the entertainment show for the Geordie presenting duo who will be back with more games, guests and live surprises.
While the show has typically relied on the presence of a live audience, the series will have a virtual studio audience of over 300 people due to the coronavirus pandemic.
Last year's run saw its final few episodes filmed without an in-person audience around the time the first lockdown kicked in for England.
Watch: 'Tickly brain!' See Ant and Dec get tested for coronavirus
The debut episode of the upcoming new series will include special guests Jamie and Harry Redknapp in a 'Get Me Out of Ear' skit which sees Ant and Dec secretly order stars around.
Take That's Gary Barlow is also on hand as the musical act for the End of the Show Show.
The programme has also teased some of the famous guests that can be expected to participate in the antics later on in the series, including Davina McCall and Sir Mo Farah.
The hosts will also star in a brand new mini-series, Double Trouble, which sees the pair cloned and their doubles going rogue. It will also feature a number of famous faces including Bear Grylls, Prue Leith, Rob Brydon, Alison Hammond and Jermaine Jenas.
Stephen Mulhern is back once more to challenge the presenters with a series of surprise Ant vs Dec tasks while X Factor star Fleur East also has her own segment.
For the first time there is set to be a sister show available on the ITV Hub where fans can expect interviews with Ant and Dec and behind-the-scenes gossip.
Ant and Dec's Saturday Night Takeaway returns to ITV at 7pm on 20 February.
Watch: Ant and Dec recreate first SM:TV live moment