Manchester City striker Gabriel Jesus misses out on a return against Arsenal after two months on the sidelines with a broken foot.
Defender John Stones has been ruled out after failing to recover from the muscle injury which forced him out of last week's Premier League victory at Southampton.
Despite Claudio Bravo having featured in the last two Premier League games, manager Pep Guardiola changes his usual cup rotation policy as Willy Caballero remains on the bench.
A groin injury means right-back Bacary Sagna does not return against his former club.
Man City starting XI: Bravo; Navas, Kompany, Otamendi, Clichy; Yaya, Fernandinho; De Bruyne, Silva, Sane; Aguero
Subs: Caballero, Zabaleta, Fernando, Sterling, Kolarov, Delph, Iheanacho
Arsenal starting XI: Cech; Gabriel, Koscielny, Holding; Oxlade-Chamberlain, Ramsey, Shaka, Monreal; Ozil, Sanchez, Giroud
Subs: Martinez, Bellerin, Gibbs, Coquelin, Walcott, Iwobi, Welbeck