Dean Smith's side are now four points adrift of safety after Watford clinched a vital victory against Norwich. They do, however, have a game in hand on the Hornets and West Ham.
Manchester United, meanwhile, are applying serious pressure to Chelsea and Leicester City in the race for a top-four finish.
Ole Gunnar Solskjaer's side have now won their last four games in succession, with teenager Mason Greenwood's goalscoring form providing another welcome boost to morale.
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When is it and what time is it?
The match will begin at 8.15pm on Thursday 9 July at Villa Park.
How can I watch it online and on TV?
The match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League following coverage of Bournemouth vs Tottenham.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
Aston Villa: Reina; Konsa, Hause, Mings, Taylor; El Ghazi, Luiz, McGinn, Trezeguet; Grealish; Samatta
Manchester United: De Gea; Wan-Bissaka, Maguire, Lindelof, Shaw; Pogba, Matic; Greenwood, Fernandes, Rashford; Martial
What are the odds?
Aston Villa - 19/2
Draw - 9/2
Manchester United - 3/10