The maths whizz and TV presenter said that she liked being able to put herself first and that being in a relationship was "just not how I'm programmed".
She told Prima magazine: "My generation was taught that we should be in a partnership, but it's rubbish. Not everyone is suited to being in a couple and if I'm being really honest, I think that's true for me. It's just not how I'm programmed.
"I like being able to put myself first and not have to ask: 'Shall we do this?' or 'Shall we do that?' So yes, I'm very happily single and won't be looking for a partner any time soon."
Vorderman, 61, has been married twice - first to Christopher Mather for a year in her early 20s, and later to Patrick King, who she has two children with.
She separated from King in 2000 and later had a five-year relationship with Des Kelly, but they split in 2007.
Former Countdown star Vorderman, known for her health and fitness regime of walking and hiking, also spoke in the interview about her struggles with long COVID in 2020 and the exhaustion she had felt, saying "it affected me really badly".
She added: "By Christmas, I was exhausted and had to take some time out...Ever since then, I've really hit the health track to try to get myself back to where I was. Now, I'm finally feeling great again, both inside and out."
Vorderman showed off her stunning Welsh coast home to her Instagram followers during lockdown, but recently revealed that she had spent many years not returning to her native Wales because of a family rift.
She said that her mother had split from her stepfather and told her not to return to Wales, but that she was now happily spending half of the year there.
Watch: Carol Vorderman and son praised for opening up on education struggles