The 26-year-old won the belt in stunning fashion from Cristofer Rosales back in December and impressed once more, winning every single round against Moreno in London.
Elsewhere, Lawrence Okolie won the commonwealth belt for a second time with a fourth round knockout of Wadi Camacho, Joshua Buatsi won the British title with an impressive third round stoppage of Liam Conroy and Lewis Ritson returned from his first career defeat with a points win at super-lightweight against German Benitez.
Recap on all the action below.
Please allow a moment for the blog to load...
When and where is the fight?
The fight is on Saturday, March 23 at the Copper Box Arena in London.
What time will the main event ring walks be?
Ring walks for the main event will take place just after 10pm.
What is the full fight schedule?
Charlie Edwards vs Angel Moreno - WBC world flyweight title
Joshua Buatsi vs Liam Conroy - British light heavyweight title
Lawrence Okolie vs Wadi Camacho - British and Commonwealth cruiserweight titles
Lewis Ritson vs German Argentino Benitez
Jason Quigley vs Mathia Eklund
Sean McGoldrick vs Sean Cairns
Shannon Courtenay vs Cristina Busuioc
Lewis Syrett vs Danail Stoyanov
Tom Ansell vs Chris Adaway