Comic Relief is asking viewers to dig deep and support some worthy causes for another year but as usual, there are plenty of hilarious TV moments lined up to encourage you to donate.
BBC has been airing various Comic Relief shows, including Tom Daley and Jordan North's gruelling sporting challenges and a celebrity special of This Is My House, all week and they culminate in tonight's main Red Nose Day broadcast on BBC One.
Highlights include some big comic partnership reunions and sketches, celebrity guest appearances and special episodes of favourite programmes.
Read more: MasterChef to return with new challenges
Here's all you need to know about Comic Relief 2022.
When is Comic Relief on TV?
Fundraising programmes and challenges have been airing over the past couple of weeks, but the main charity night broadcasts tonight (Friday, 18 March) from 7pm on BBC One.
Who is presenting Comic Relief 2022?
As usual, the main host on the night will be the fundraiser's founder, Sir Lenny Henry.
This year, he'll be joined in the studio by a team of presenters who include Alesha Dixon, David Tennant, and Paddy McGuinness. Zoe Ball has pulled out of the show after catching COVID.
The Great Comic Relief Prizeathon, a mash-up of live music, comedy sketches and text-to-win prize draws, was due to be hosted by Joel Dommett and AJ Odudu, but Dommett has now been ruled out after a positive COVID test and will be replaced by Vernon Kay.
What are the TV highlights to look out for?
One of the most anticipated parts of the night is the return of Rock Profile, which sees David Walliams and Matt Lucas back together in one of their earliest comic sketches.
A promo picture shows the duo, who don't often work together any more, in costume as father and daughter Billy-Ray and Miley Cyrus.
Vernon Kay joins them as interviewer, with other characters taken on by the comedians including Adele, Lady Gaga and Lewis Capaldi.
The Repair Shop
A BBC favourite gets the Comic Relief treatment as the beloved programme hosted by Jay Blades welcomes guests Dawn French and Jennifer Saunders in character as The Extras — a pair of elderly women who are looking to fix a toaster with sentimental value.
First-look pictures from the sketch also show Dame Judi Dench joining French and Saunders in what is sure to be a highlight of the evening.
The Comic Opera is back for a second year, and this time it has an all-female cast.
Celebrities are given just 24 hours to master one of the world's most famous arias from Carmen before performing it for opera fans at the London Coliseum, which will be broadcast live tonight.
Scarlett Moffatt, Nina Wadia, Tamzin Outhwaite, Rosie Jones and Helen George will take on the singing challenge, with support and hosting from Sara Cox.
Strictly Come Dancing fans won't want to miss this beautiful performance from their 2021 champions Rose Ayling-Ellis and Giovanni Pernice.
The winning couple are back together to dance a waltz to Ellie Goulding’s How Long Will I Love You in the Comic Relief studio.
Jack Whitehall's Mini Golf Challenge
Comedian Jack Whitehall welcomes two very special guests to the mini golf course — Premier League players and childhood best friends Mason Mount and Declan Rice.
They will go head-to-head in the golfing challenge, with a big forfeit in store for the loser.
Look out for Kylie Minogue appearing in a special new episode of sitcom Ghosts, where she'll join the eternal residents of Button House.
Stephen Fry and a host of other special guests line up something for younger viewers as they read the CBeebies Bedtime Story.
Hit panel show QI sees host Sandi Toksvig joined by Alan Davies, Jo Brand, Sally Phillips and Guz Khan to look back at some quirky fundraising events from years gone by.
The cast of West End musical & Juliet join the studio to perform a medley of hits from their must-see show.
Of course, the schedule also includes some emotional updates from projects the charity supports around the UK and across the world in Kenya, South Africa, Uganda and India.
You can donate to Red Nose Day by visiting bbc.co.uk/rednoseday
Comic Relief airs tonight from 7pm on BBC One.
Watch: Tom Daley discusses gruelling Comic Relief trek