There should be no return to the coronavirus tier system, London mayor Sadiq Khan has said as he branded it a "catastrophic failure".
Boris Johnson is expected to announce a roadmap out of the latest national lockdown on Monday.
He has indicated he will proceed with a national approach rather than a return to tiers, saying a whole-country system "might be better this time round".
Watch: Labour leader fears England tier system 'not strong enough'.
Khan said on Friday: "I think the government’s tiering system hasn’t worked, it has been a catastrophic failure and that’s why I think we need to look towards the country as a whole.
"The reality is what we can’t do is lift lockdown because we’ve seen good progress in one part of the country, which inadvertently leads to a lack of progress in another part of the country.
"I think we’ve got to learn the lessons of the mistakes made in the past."
Khan's comments echo earlier sentiments from Greater Manchester mayor Andy Burnham, who has called for a national approach rather than regional measures depending on local infection rates.
Professor Dame Angela McLean, chief scientific adviser at the Ministry of Defence, told the House of Commons Science and Technology Committee this week that the government was too slow to move areas into higher tiers under the previous system.
She said: “It was the way we used the tier system – we waited until prevalence was high before putting it into a more restrictive tier.
“What we should have done was say: ‘Look, this part of the country, the number of infections is starting to grow’, and (we should have) put them into higher tiers while their infection (rates) were still low.”
She added: “It was the way that we used the tier system that we need to do different this time – to use the tiers to act when prevalence is low but growing.”
In November, experts criticised the tier system, saying it "was not very well thought out".
Professor John Edmunds, a member of the Scientific Advisory Group for Emergencies (Sage), said at the time: "The problem with the tier system is Tier 1 doesn't do much at all, Tier 2 probably has some effect, but not a great deal, and Tier 3 seems to be able to hold the epidemic.
"The problem with the tier system is that inevitably you end up with quite a lot of places with high incidence under those circumstances.
"Because the Tier 1 and Tier 2 ones just eventually drift up into Tier 3 with a high incidence, and then Tier 3 holds it there."
He added: "It wasn't a very well thought through strategy, frankly."
Watch: What you can and can't do during England's third national lockdown