The pair, who played on-screen friends-turned-married-couple Monica Geller and Chandler Bing on the much-loved sitcom Friends, reunited for lunch and documented the moment with a sweet snap.
The smiling photo saw the actors posing in the sun in front of a leafy backdrop - and naturally Cox's social media followers could not help but get excited over the rare picture.
Cox made a nod towards one of Perry's character's iconic lines in her Instagram caption, writing: “Guess who I had lunch with today....I KNOW!! Could I BE any happier? #realfriends.”
It gained a very quick response from their former co-star Lisa Kudrow who commented: “Lucky lucky. #beautifulpeople.”
Fellow Friends star Jennifer Aniston, who joined Instagram last month, added: "MATTY!! I LOVE YOU, GUYS.!
Modern Family star Eric Stonestreet also commented, writing: "High quality content!"
One fan also referred to a hilarious moment from the sitcom in which Chandler struggles to pose for an engagement photo with Monica, writing: "Chandler finally learned how to smile in front of the camera."
It was the first Friends reunion of the day for Cox, who later joined Aniston and Kudrow on the red carpet at the SAG AFTRA Foundation's Patron of the Artists Awards, where Aniston was honoured with an Artists Inspiration Award.
In a recent interview with the Radio Times, Aniston spoke about the initial pay gap between the lead cast on the show.
The Friends cast famously raised the bar for salary appraisals over the course of the noughties sitcom, as the six stars negotiated together to eventually score a payday of $1 million per episode each. However, it wasn’t always equal.
Speaking to the magazine to promote her upcoming role on The Morning Show, Aniston said, “I’m aware that I have had a pretty easy time in terms of my experience in the business. But even back on Friends, it wasn’t so much about women being paid the same as men - some of the women were being paid more.”
The Friends cast began negotiating their contracts as a group from season three onwards to ensure they were earning the same amount. While they were initially paid $22,500 per episode in season one, according to People magazine, Jennifer Aniston and her co-star David Schwimmer began earning more than their colleagues in season two.
The gap between Aniston, Schwimmer and the rest of the group led the cast to renegotiate for equal pay with a 1996 New York Times report claiming the stars even threatened “not to show up for the taping of the new season’s shows”.
Aniston continued, “[The negotiatons were] more about, ‘We’re doing equal work and we all deserve to be compensated in the same way.’ I wouldn’t feel good going to work knowing someone was getting x amount and I was getting something greater.”
Aniston has returned to television with her upcoming series The Morning Show, which will see her play a news anchor at a network reeling from allegations levelled against her character's colleague.
She is also a producer on the series, alongside her co-star and fellow producer Reese Witherspoon (who starred as Rachel Green's sister on Friends), and the show launched on Apple TV on November 1.